Steve, Blue, Tickety, Slippery, and the viewers become the Thinking Squad, a group of superheroes who use their brains to figure out problems. When they hear a mysterious noise, they play Blue's Clues and use their skills to figure out where the sound is coming from.
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This episode is the first appearance of Paprika since the third season. Her previous voice actress, Jenna Marie Castle, has now been replaced by Corrine Hoffman.
The episode's title is based on the 1970s cartoon Superfriends.
Kathryn Avery has officially been replaced by Kelly Nigh for the voice of Tickety since Blue's Big Musical.