The series premiere opens with Josh inviting the viewers into the house. Suddenly, he does not see Blue. The viewers saw her under the table. Blue comes out from under the table. Then, she sits her seat. Josh and Blue were going to have graham crackers for snack. Blue tells Josh she wants something else with her snack. So Josh doesn't know what to do so he calls Steve & Joe & they tell Blue & then him to play Blue's Clues. The viewers along with Steve & Joe learn Josh how to play the game. They have to find a paw print which was the first clue. Then, they have to draw it in the notebook. Next, they have to find another paw print being the second clue and draw in the notebook. Then, they have to find one more paw print being the third clue and draw it in the notebook. After that, they go to the thinking chair and put all three clues together.
Now that the viewers, Steve & Joe know how Josh has to play the game, Josh leads them into the bedroom. The viewers saw a clue on the cup. Josh draws the cup in his handy dandy notebook. After drawing the first clue, Josh wonders what Blue could have with her snack. Josh realizes that Blue wants to put something into the cup. They had to find two more clues. Josh was looking for Blue again. The viewers find a sudden sound startles him and falls down backwards onto the floor. He realizes that it was the telephone. Josh answers it and finds out it was Mr. Salt and Mrs. Pepper calling. They tell Josh that Blue is in the kitchen and is making a really big mess.
Josh goes to the kitchen and then asks Blue when she had done. "Blue knocked over the grocery bag" said Mr. Salt. "That's what she did" added Mrs. Pepper. It was time to clean up the mess. The foods were in different shapes. One-by-one, they put away all the different foods into the fridge. The orange was shaped like a circle. The Swiss Cheese was shaped like a square. The graham cracker was shaped like a rectangle. And the grapes were shaped like a triangle. They all went into the fridge. Once all the food was put away, it made a house. The square Swiss cheese for the house, the triangle grapes for the roof, the rectangle graham cracker for the door and the orange for the sun. Blue comes out of the house made of food and knocks something else down. Josh saw what Blue knocked over. It was the straws. Josh picks up the cup and stands it on the counter. Next, he picks up the straws and puts them back in the cup. Josh thought he put away all the straws but then the viewers saw another straw with paw prints. Whenever Josh tries to find where the straw is hiding, it switches sides. Josh peeks between the straws and finds the straw with the paw prints on it which was the second clue. He draws the straw in his notebook. So far, Josh has a cup and straw as the two clues. Josh realizes that with these two clues, Blue wanted something to drink. Then, it is mail time.
Josh gets his letter from Mailbox. Josh reads the video E-mail which had kids said hi to Josh. After reading the E-mail, Blue skidoos into a picture frame that shows a farm. Josh follows her. He skidoos too. There was a pig who jumped into a mud puddle. There was a sheep who ate a flower. Then, he saw a swarm of chicks. One of them had a paper hat on. Josh sits down and the chick who wore a paper hat lands on Josh's hand he was holding out. The chick was trying to find her friend who wore a newspaper hat that she has on. After a couple of tries, she finds her friend. They were a good matching pair. They also help a chick who had a baseball cap with a star on it find his friend and one who wore a party hat find its friend too. Now, Josh needed help finding Blue. Blue was on Josh's head. Blue gets off of Josh's head as he stands up. As Josh was looking for Blue, he finds paw prints on a cow. A cow was the third clue. Josh draws the third clue, a cow, in his notebook.
Now that he has all three clues, Josh and Blue have to skidoo back home and sit in the thinking chair to figure out what Blue wants with her snack. They both did so. Now, that they were in the thinking chair, it was time to think. The clues were a cup, a straw and a cow. "What does Blue want with her snack?" Josh wonders. Josh thought Blue wants to put the cow in the cup and slurp it up with a straw. That did not make any sense. What they do know is cows makes the sound, "moo". So, what could Blue want with her snack that comes from a cow, you drink with a straw in a cup? The answer was milk because cows make the milk that gets poured into a cup. And that you drink it with or without a straw. They just figured out Blue's Clues. Now, it was snack time. Josh had two cups filled with milk. One for himself and one for Blue. Blue sits at the table and drinks her cup of milk with a straw. Suddenly, Magenta ; followed by Mr. Salt, Mrs. Pepper, Paprika & Cinnamon, and the shape foods they put away earlier, then, the chicks also came. They all had different hats on as Josh receives a call from Steve & Joe & asking him did he figure it out & Josh says it was Milk with a little help from his friend, Steve, Joe & Josh sings the "So Long song" and the episode ends.
The bags holding the food are also made of recycled cloth instead of paper.
The straw that was used for the second clue was visible when Josh puts back the other straws in the cup. In the original, the straw that was used was hidden until Steve put all the straws in the cup.
The straw is a straight one made of paper instead of a bendy one made of plastic and is with lavender diagonal stripes instead of red vertical ones. The rest of the straws are similar to this one, but are larger and thicker with stripes in red and blue in addition to lavender.
In the original episode, after Steve finds the second clue, he goes to the living room and looks for Blue, then Mailtime begins. In the reboot, Mailtime came immediately after the second clue.
When Steve skidooed in the farm, he sang "We Are Farming for Blue's Clues" to the tune of "We Are Looking for Blue's Clues" until "E-I-E-I-O" and the rest to the tune of "Old MacDonald Had a Farm", where as Josh sings it to the tune of "Old MacDonald Had a Farm", starts on the second verse and replaces "And on his farm he had a chick" with "We are farming for Blue's Clues".
In the skidoo segment, there are yellow and brown chicks and all of them are wearing party hats. In the original, all the chicks are yellow and are wearing different kinds of hats.
Josh helps only two chicks look for their friends. In the original, Steve helps three chicks. This is one chick less than in the original.
After Josh asks the chicks to help him look for Blue, the chicks immediately answered that Blue is on top of Josh's head. In the original, the chicks asked Steve to describe his friend and then tell him that she is on his head.
Josh does not interact with Sidetable Drawer because he had his notebook/phone with him already.
In the original episode, Steve hears the viewers saying "A clue!" well for all three clues. In the reboot, Josh mishears the viewers saying "A clue!" for the third clue, then imitates a rooster. (A cack-a-doodle-doo)
Steve wears a green-striped tie with a beige suit and fedora.
Steve is a detective, and Joe is a present store owner working at a present store. It’s implied Steve studied criminal justice in college.
Steve and Joe look different from the last time they were seen on the original show. For example, Steve's now bald, wears glasses, wears a green-striped tie and tan pants only under his detective clothes, and Joe has a haircut. He still wears his same clothes from the original series Blue's Clues, but with gift boxes instead of squares on his shirt.