Grandma Cayenne is a cayenne shaker and the female grandparent of Paprika and Cinnamon. She, like her child Mrs. Pepper and her son-in-law Mr. Salt, is French. The character can cook many dishes and cares about her child and grandchildren. She apparently has never met Joe because she made her only appearance before he took over the role of Steve as host of Blue's Clues in the fifth season of the series.
Grandma Cayenne is a brown color. She wears pink glasses and has a white cap with five gray holes. The character has two black arms with one hand on each arm. There are three fingers on each of her hands.
- She is probably the oldest character in the show, aside from Steve's Grandmother.