- Executive Producers: Traci Paige Johnson, Todd Kessler, Angela C. Santomero
- Executive Producers: Vince Commisso, Wendy Harris, Jennifer Twomey
- Series Director: Vadim Kapridov
- Directed by: Jeremy Slutskin, Jennifer Sherman
- Starring: Josh Dela Cruz as Josh
- Supervising Producer: Shevaun Gray
- Series Producers: Paula Tomiko Potts, Lesley Saliwonchyk
- Line Producers: Eric Gomes, Kyle Whaley
- Producers: Ana Voci, Jackie Payton
- Production Manager: Breanne Hutchins
- Associate Producer: Maddie Kroll
- Production Coordinators: Holly Pace, Thomas Stroud
- Head Writer: Kevin Del Aguila
- Story Editor: Caitlin Hodson
- Staff Writer: Alyson Piekarsky
- Script Coordinator: Darnell Lamont Walker
- Research & Curriculum Director: Jess deMonsabert, PhD
- Research & Curriculum Associate Director: Noriko Louison
- Research Coordinator: Sheryl McGloffin-Pinto
- Research Analyst: Veronika Telser-Gadow
- Research Assistant: Zoe Steckler
- Research Artist: Amanda Summers
- Curriculum Consultant: Rebecca Coryea M.S.ED.
- Special Guest: Mapbook: Steve Burns
- Character Voices
- Blue: Traci Paige Johnson
- Rainbow Puppy: Brianna Bryan
- Mailbox: Doug Murray
- Shovel: Leo Orgil
- Pail: Jordana Blake
- Tickety Tock: Ava Augustin
- Slippery Soap: Jacob Soley
- Periwinkle: Luxton Handspiker
- Josh's Friends: Eliot Dahan, Emma Mackness, McKenzie Cornelius
- Voice Director: Alyson Court
- Casting by: Alyson Court, Millie Tom, Lindsay Furest, CSA, Michelle Levitt, CSA, Ann Maney, CSA, Danielle Pretsfelder, CSA, Julie Rose, CSA
- Casting Associate: Beth Benge
- Shoot Board Artist: Kanako Iwata
- Storyboard Supervisor: Wen Ling Lim, Chris Ramsarran
- Board Revisionists: Eduardo Espinoza, Elizabeth Parkes, Adarsh Peter, Michael Tampoya
- Art Director: Vladimir Kato
- Funpack Designers: Dilraj Gahunia, Kalle Malloy
- Design Supervisor: Justin Darbyson-Billingham
- Modeler/Surfacer: Alexis Patoine
- Designers: Justin Darbyson-Billingham, Rachel Joseph, Melissa Lee, Myrthus Nacario
- Layout Supervisor: Denis Gagne
- Layout Artists: Yunho Jeong, Andrew Manzanares
- Background Supervisor: Meg Simmons
- Background Painters: Justin Mark, Danny Silva
- 3D Rigger: Andrzej Kloc
- 2D Rigging Supervisor: Natalie Pasko
- 2D Riggers: TJ Ahn, Semar Chahrour, Lisha Lin, Inna Testolini
- Scene Set-Up Artist: Brad Zimmerman
- 2D Animation Supervisors: Huy Tran, Mike Yunker
- 2D Lead Animator: Matthew Da Silva
- 2D Animators: Leah Alcantara, Annette Bede-Fazekas, Mike Binsted, Jenelle Cardinal, Elizabeth Da Ponte, Wincy Li, Erin Switalski
- FX Animator: Justin Salgado
- 3D Animation Supervisor: Barry A. Sanders
- 3D Lead Animators: Rebecca Yau, Christopher Wolfe
- 3D Animators: Denis Bejtic, Peter Floyd, Chip Georgescu, Derek Gowland, Heather Leach, Jenna Livingston, Jeff McIntyre, Dean Parent, Will Postma, Haley Skinkle, Elisa Almeida Ucci, Kevin Winter
- CG Supervisor: Zebulon Pike
- Compositing Supervisor: Elina Iskoz
- Asset Supervisor: Kosta Lavrinuk
- 3D Generalist: Brendan Jackson
- Compositors: Robert Dale, Nathan Day, Eshan Dissanayake, Kadelle Liburd, Khoi Mai, Henrique Obuti, Neetha Shankar, Samantha Skinner, Emily Tersigni
- Live Action Crew
- Line Producer: Patrick R. Quinn
- 1st Assistant Director: James Rait
- Director of Photography: Simon Riera
- 2nd Assistant Camera: Jason MacFarlane
- Script Supervisor: Soo-Won Lee
- Digital Media Technician: Adam DeLisle
- Sound Recordist/Mixer: Carlos Valdez
- Creative Consultant: Steve Wright
- Key Hair & Make-Up: Kerry Vaughan
- Daily Hair & Make-Up: Justyna Pakula
- Costume Designer: Alexis Yamamoto
- Assistant Costume Designer: Alina Yakus
- Talent Assistant: Ashley Kranz
- Production Coordinator: Devika Smith
- Production Assistant: Jillian Katsis
- Property Master: Samantha Roddick
- Prop Builder: Mike Law
- Prop Assistant: Carla Jacob
- Gaffer: Kendall McColl
- Key/Dolly Grip: Steve Clark
- Clue Drawings by: Jason Charles Hatton
- Opening Sequence Choreographer: Amy Wright
- Catering: Mimico Foods Co.
- Covid Compliance Officer: John Dutka
- Director of Technology: Sean Macrae
- IT Manager: Renee Nakatsu
- Technical Directors: Howard Cassidy, Mathieu Reygaerts
- Technical Support: Chris Brown, Gene Hunter Crawford III, Lauren Cruz, Gavin Myles, Sahal Omar, Chris Quirk, Mark Roy, Sherrill Sheng
- Pipeline Technical Team: Patrick Hart, Eric Harvey, Andrew Klaassen, Jason Lin, Danielle Mahaffey, Kathleen Tran
- Render Wranglers: Akito Roberge, Kirk Price
- Head of Post Production: Allison Nantais
- Post Production Supervisor: Sean Tolhurst
- Post Production Coordinators: Meabh Boyle, Khanh Huynh
- Editors: Deanna Scriver, Dan Silver
- Assistant Editor: Phil James
- Online Editor: James Naylor
- Audio Post Production: Beatstreet NYC
- Audio Post Production Supervisor: Joe Franco
- Supervisor Sound Editor: Matt Longoria
- Re-Recording Mixers: Matt Longoria & Jackson Roe
- Dialogue & Music Editors: David Britton & Matt Longoria
- Sound Effects & Foley: Jackson Roe
- Assistant Sound Editor: Max Bell
- Music by: PT Walkley
- Arrangements by: PT Walkley
- Theme Song Written and Produced by: Peter Zizzo
- Based on Music by: Mike Rubin and Nick Balaban
- Business & Legal Affairs: Melissa Taylor, Roni Hoffman, Krista Barron
- Supervising Producers: Nisa Contreras, Martin Sal
- Production Accounting: Ally Hausen, Kimberley Ah-Chong, Maryann Comuniello, Nicholas Faught, Shelley Anderson
- Executive Assistants: Brittany Groveman, Jennifer Puckett, Rosalie Rubinstein
- Consulting Producers: Nora Keely, Marcy Pritchard, Steve Burns, Vadim Kapridov, Jennifer Sherman
- Special Thanks: Pie In The Sky Studio, Sign Language Center, Our Research Participants, Luis Bermudez
- For Nickelodeon
- Director, Preschool Production & Development: Marielle Kaar
- Sr. Director, Animation Production: Kelly-Ann Fentress Krawchuck
- Manager, Animation Production: Jennifer Burke
- Special Thanks: Brian Robbins, Ramsey Naito, Brian Keane, Eryk Casemiro, Angelique Yen
- Vice President of Animation Production: Patty Henry-Robinson
- Executive in Charge for Nickelodeon: Sarah Landy
- ©2022 ViacomCBS International Inc. All Rights Reserved. Nickelodeon, Blue's Clues & You!, and all related titles, logos and characters are trademarks of ViacomCBS International Inc.