Nickelodeon held an open casting call for a potential host on April 14, 2018. The auditions were held at their studio in Burbank, California. The network sought applicants 18-25 years old of all ethnicities.
Like the original show, there will be a live-action host in an animated world. The reboot will feature all-new production design and animation. The visual style will remain true to the original, but the characters will be rendered in CGI, as depicted in a teaser image.
Blue and the Shaker family were confirmed to be returning for the reboot at Nickelodeon's upfront presentation. Additionally, Mailbox and Tickety have been mentioned in sneak-peek videos of the reboot's production from Nickelodeon's YouTube channel, but their new designs have not been revealed. Sidetable (minus the telephone) has also been confirmed for the reboot according to a YouTube review video. On September 13, 2018. Nickelodeon announced the new host would be Joshua Dela Cruz, along with the new title, Blue's Clues & You!.